Los Angeles Chargers vs New York Giants Prediction – 9/28/2025

The Los Angeles Chargers will put their unbeaten record on the line against the winless New York Giants on Sunday. This Week 4 matchup is the second road test of the season for the Chargers. They will have to overcome a hostile environment and some injury concerns against a Giants team that is desperate to finally get into the win column. Here, I take a closer look at this matchup and bring you my Chargers vs Giants prediction for Sunday’s game.

Our Chargers vs Giants Pick

• Pick: Under 44.5
• Confidence: ★★★★☆

Game Snapshot

• Matchup: Los Angeles Chargers vs New York Giants
• Date & Time: Sunday, September 28, 2025, 1:00 PM ET
• Venue: MetLife Stadium, East Rutherford, NJ
• Broadcast: CBS

Chargers vs Giants Odds

Key Storylines

• Chargers’ hot start: Los Angeles is 3-0 for the first time since 2002. They’ve taken down all three of their fellow AFC West teams so far. That is huge not just in terms of wins and losses, but in terms of potential tiebreakers later in the season.
• Giants offense in disarray: New York has been held to single digits in two of its three games and totaled just nine points at home against Kansas City in Week 3. Russell Wilson threw two interceptions in that game and the Giants will need him to be more effective to have a shot here.
• Defensive vulnerabilities: The Giants are allowing 27.7 points per game this season. Their defense ranks among the worst in yards allowed and passing yards allowed. Facing Justin Herbert might not fix things for them.
• Chargers key injuries and adjustments: Los Angeles lost Najee Harris to an Achilles injury against the Denver Broncos in Week 3. Mekhi Becton is also questionable with a concussion and offensive injuries could slow the Bolts down this week.

Quarterback Play

Justin Herbert has been electric so far in 2025. Over three games, he’s thrown for 860 yards, six touchdowns, and just one interception. He’s completed two-thirds of his passes and he’s averaged over eight yards per attempt.

Russell Wilson has not found much rhythm through three weeks as the quarterback of the Giants. Wilson has three touchdowns and three interceptions on the year and that is nowhere near good enough for New York. There’s also growing pressure for Jaxson Dart to step in and those rumblings will only grow louder if Wilson continues to struggle.

Betting Trends & H2H

• The Chargers are 3-0 straight up and against the spread thus far this season.
• The Giants are 0-3 straight up and 1-2 against the spread early on.
• Both teams have gone under the total in two of their first three games.

Chargers vs Giants Model Projection

Score Projection: Chargers 24 – Giants 17

Win Probability: Chargers 78%, Giants 22%

Final Thoughts

I would expect the Chargers to win this game and stay unbeaten. The Giants just don’t have the consistent offense needed to outperform Herbert and the Chargers right now. But instead of taking a side here, I think that the under is a better bet. Los Angeles’ defense will get pressure on Wilson and cause the Giants to struggle, allowing the Chargers to play a slow, methodical game en route to an under.

Jay Sanin

Jay Sanin is a sports bettor, writer and broadcaster from New York. He is an avid New York Knicks fan and is no longer ashamed to admit it. He is also an avid New York Giants fan, and is very ashamed to admit it. His top sports to handicap are the NBA, WNBA and men’s tennis for some reason. He has watched more UAlbany Great Danes basketball than anyone should consume.

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• Source: https://ats.io/nfl/los-angeles-chargers-vs-new-york-giants-prediction-9-28-2025/468024/